SELECTED PUBLICATIONS
Some of our highlighted publications. For a complete list, please refer to PubMed or Google Scholar.
* Denotes a member of the Harper Lab at the time of publication
16P11.2 HAPLOINSUFFICIENCY REDUCES MITOCHONDRIAL BIOGENESIS IN BRAIN ENDOTHELIAL CELLS AND ALTERS BRAIN METABOLISM IN ADULT MICE
2023
Authors: Alexandria Béland-Millar, Alexia Kirby, Yen Truong, Julie Ouellette, Sozerko Yandiev, Khalil Bouyakdan, Chantal Pileggi*, Shama Naz, Melissa Yin, Micaël Carrier, Pavel Kotchetkov, Marie-Kim St-Pierre, Marie-Ève Tremblay, Julien Courchet, Mary-Ellen Harper*, Thierry Alquier, Claude Messier, Adam J Shuhendler, Baptiste Lacoste
Journal: Cell Reports
PARKIN COREGULATES GLUTATHIONE METABOLISM IN ADULT MAMMALIAN BRAIN
2023
Authors: Daniel N El Kodsi, Jacqueline M Tokarew, Rajib Sengupta, Nathalie A Lengacher, Ajanta Chatterji, Angela P Nguyen, Heather Boston, Qiubo Jiang, Carina Palmberg, Chantal Pileggi*, Chet E Holterman, Bojan Shutinoski, Juan Li, Travis K Fehr, Matthew J LaVoie, Rajiv R Ratan, Gary S Shaw, Masashi Takanashi, Nobutaka Hattori, Christopher R Kennedy, Mary-Ellen Harper*, Arne Holmgren, Julianna J Tomlinson, Michael G Schlossmacher
Journal: Acta Neuropathologica Communications
NOVEL HOMOZYGOUS VARIANT IN COQ7 IN SIBLINGS WITH HEREDITARY MOTOR NEUROPATHY
2023
Authors: Ian C Smith, Chantal A Pileggi*, Ying Wang, Kristin Kernohan, Taila Hartley, Hugh J McMillan, Marcos Loreto Sampaio, Gerd Melkus, John Woulfe, Gaganvir Parmar*, Pierre R Bourque, Ari Breiner, Jocelyn Zwicker, C Elizabeth Pringle, Olga Jarinova, Hanns Lochmüller, David A Dyment, Bernard Brais, Kym M Boycott, Siegfried Hekimi, Mary-Ellen Harper*, Jodi Warman-Chardon, Care4Rare Canada Consortium
Journal: Neurology Genetics
EXERCISE TRAINING ENHANCES MUSCLE MITOCHONDRIAL METABOLISM IN DIET-RESISTANT OBESITY
2022
Authors: Chantal A Pileggi*, Denis P Blondin*, Breana G Hooks*, Gaganvir Parmar*, Irina Alecu, David A Patten, Alexanne Cuillerier, Conor O'Dwyer, A Brianne Thrush*, Morgan D Fullerton, Steffany AL Bennett, Éric Doucet, François Haman, Miroslava Cuperlovic-Culf, Ruth McPherson, Robert RM Dent, Mary-Ellen Harper*
Journal: eBioMedicine
ASSOCIATION OF MUSCLE FIBER TYPE WITH MEASURES OF OBESITY: A SYSTEMATIC REVIEW
2022
Authors: Alameen Damer, Sherif El Meniawy, Ruth McPherson, George Wells, Mary‐Ellen Harper*, Robert Dent
Journal: Obesity Reviews
TARGETING SKELETAL MUSCLE MITOCHONDRIAL HEALTH IN OBESITY
2022
Authors: Chantal A Pileggi*, Breana G Hooks*, Ruth McPherson, Robert RM Dent, Mary-Ellen Harper*
Journal: Clinical Science
PROHIBITIN 1 INTERACTS WITH P53 IN THE REGULATION OF MITOCHONDRIAL DYNAMICS AND CHEMORESISTANCE IN GYNECOLOGIC CANCERS
2022
Authors: Bao Kong, Chae Young Han, Se Ik Kim, David A Patten*, Youngjin Han, Euridice Carmona, Dar-Bin Shieh, Annie C Cheung, Anne-Marie Mes-Masson, Mary-Ellen Harper*, Yong Sang Song, Benjamin K Tsang
Journal: Journal of Ovarian Research
FOXO3A TEMPERS EXCESSIVE GLUTAMINOLYSIS IN ACTIVATED T CELLS TO PREVENT FATAL GUT INFLAMMATION IN THE MURINE IL-10−/− MODEL OF COLITIS
2022
Authors: Stephanie Hajjar, Nayanan Nathan, Julie Joseph, Walid Mottawea, Ardeshir Ariana, Sergey Pyatibrat, Mary-Ellen Harper*, Tommy Alain, Alexandre Blais, Ryan C Russell, Subash Sad
Journal: Cell Death & Differentiation
NAKED MOLE-RAT BROWN FAT THERMOGENESIS IS DIMINISHED DURING HYPOXIA THROUGH A RAPID DECREASE IN UCP1
2021
Authors: Hang Cheng, Rajaa Sebaa*, Nikita Malholtra, Baptiste Lacoste, Ziyad El Hankouri*, Alexia Kirby, Nigel C Bennett, Barry van Jaarsveld, Daniel W Hart, Glenn J Tattersall, Mary-Ellen Harper*, Matthew E Pamenter
Journal: Nature communications
GRX2 REGULATES SKELETAL MUSCLE MITOCHONDRIAL STRUCTURE AND AUTOPHAGY
2021
Authors: Ava Liaghati*, Chantal A Pileggi*, Gaganvir Parmar*, David A Patten*, Nina Hadzimustafic*, Alexanne Cuillerier, Keir J Menzies, Yan Burelle, Mary-Ellen Harper*
Journal: Frontiers in Physiology
A RECURRENT DE NOVO ATP5F1A SUBSTITUTION ASSOCIATED WITH NEONATAL COMPLEX V DEFICIENCY
2021
Authors: Matthew A Lines, Alexanne Cuillerier, Pranesh Chakraborty, Turaya Naas, M Laura Duque Lasio, Jean Michaud, Chantal Pileggi*, Mary-Ellen Harper*, Yan Burelle, Tomi L Toler, Neal Sondheimer, Heather P Crawford, Francisca Millan, Michael T Geraghty
Journal: European Journal of Human Genetics
DIETARY COCOA FLAVANOLS ENHANCE MITOCHONDRIAL FUNCTION IN SKELETAL MUSCLE AND MODIFY WHOLE-BODY METABOLISM IN HEALTHY MICE
2021
Authors: Frédéric Nicolas Daussin, Alexane Cuillerier, Julianne Touron, Samir Ben Said, Bruno Melo, Ali Al Rewashdy, Goutham Vasam, Keir J Menzies, Mary-Ellen Harper*, Elsa Heyman, Yan Burelle
Journal: Nutrients
CARDIOMYOCYTE-SPECIFIC SRSF3 DELETION REVEALS A MITOCHONDRIAL REGULATORY ROLE
2021
Authors: Audrey‐Ann Dumont, Lauralyne Dumont, Delong Zhou, Hugo Giguère, Chantal Pileggi*, Mary‐Ellen Harper*, Denis P Blondin, Michelle S Scott, Mannix Auger‐Messier
Journal: FASEB- Federation of American Societies for Experimental Biology
EXERCISE TRAINING AND DIET-INDUCED WEIGHT LOSS INCREASE MARKERS OF HEPATIC BILE ACID (BA) SYNTHESIS AND REDUCE SERUM TOTAL BA CONCENTRATIONS IN OBESE WOMEN
2021
Authors: Kelly E Mercer, Adrianna Maurer, Lindsay M Pack, Kikumi Ono-Moore, Beverly J Spray, Caitlin Campbell, Carol J Chandler, Dustin Burnett, Elaine Souza, Gretchen Casazza, Nancy Keim, John Newman, Gary Hunter, Jose Fernadez, W Timothy Garvey, Mary-Ellen Harper*, Charles Hoppel, Sean H Adams, John Thyfault
Journal: American Journal of Physiology-
Endocrinology and Metabolism
INTERINDIVIDUAL VARIABILITY IN WEIGHT LOSS IN THE TREATMENT OF OBESITY
2021
Authors: Mary-Ellen Harper, Ruth McPherson, Robert Dent
Journal: Am J Clin Nutr.
SMN DEPLETED MICE OFFER A ROBUST AND RAPID ONSET MODEL OF NONALCOHOLIC FATTY LIVER DISEASE
2021
Authors: Marc-Olivier Deguise, Chantal Pileggi*, Yves De Repentigny, Ariane Beauvais, Alexandra Tierney, Lucia Chehade, Jean Michaud, Maica Llavero-Hurtado, Douglas Lamont, Abdelmadjid Atrih, Thomas M Wishart, Thomas H Gillingwater, Bernard L Schneider, Mary-Ellen Harper*, Simon H Parson, Rashmi Kothary
Journal: Cellular and Molecular Gastroenterology and Hepatology
ROLE OF GLUTATHIONE IN CANCER: FROM MECHANISMS TO THERAPIES
2020
Authors: Luke Kennedy*, Jagdeep Sanhu, Mary-Ellen Harper* and Miroslava Cuperlovic-Culf
Journal: Biomolecules
EFFECTS OF COBALT AND CHROMIUM IONS ON GLYCOLYTIC FLUX AND THE STABILIZATION OF HYPOXIA-INDUCIBLE FACTOR-1Α IN MACROPHAGES IN VITRO
2020
Authors: Zeina Salloum, Eric A Lehoux, Mary‐Ellen Harper, Isabelle Catelas
Journal: Journal of Orthopaedic Research
THE LIFECYCLE OF SKELETAL MUSCLE MITOCHONDRIA IN OBESITY
2020
Authors: Chantal Pileggi*, Gaganvir Parmar*, and Mary-Ellen Harper*
Journal: Obesity Reviews
INNATE IMMUNE NOD1/RIP2 SIGNALING IS ESSENTIAL FOR CARDIAC HYPERTROPHY BUT REQUIRES MITOCHONDRIAL ANTIVIRAL SIGNALING PROTEIN FOR SIGNAL TRANSDUCTIONS AND ENERGY BALANCE
2020
Authors: Han-Bin Lin, Kotaro Naito, Yena Oh, Gedaliah Farber, Georges Kanaan, Alan Valaperti, Fayez Dawood, Liyong Zhang, Guo Hua Li, David Smyth, Mark Moon, Youan Liu, Wenbin Liang, Benjamin Rotstein, Dana J Philpott, Kyoung-Han Kim, Mary-Ellen Harper*, Peter P Liu
Journal: Circulation
Pubmed: https://pubmed.ncbi.nlm.nih.gov/33070627/
FACTORS AFFECTING WEIGHT LOSS VARIABILITY IN OBESITY
2020
Authors: Robert Dent, Ruth McPherson and Mary-Ellen Harper*
Journal: Metabolism Clinical and Experimental
ALTERED MITOCHONDRIAL FUSION DRIVES DEFENSIVE GLUTATHIONE SYNTHESIS IN CELLS ABLE TO SWITCH TO GLYCOLYTIC ATP PRODUCTION
2020
Authors: David A. Patten*, Shawn McGuirk, Ujval Anilkumar, Ghadi Antoun*, Karan Gandhi*, Gaganvir Parma*, Mohamed Ariff Iqbal, Jacob Wong, Richard B.Richardson, Julie St-Pierre, Ruth S.Slack, Mary-Ellen Harper*
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Link: https://www.sciencedirect.com/science/article/pii/S0167488920302123
PHENOMIC SCREEN IDENTIFIES A ROLE FOR THE YEAST LYSINE ACETYLTRANSFERASE NUA4 IN THE CONTROL OF BCY1 SUBCELLULAR LOCALIZATION, GLYCOGEN BIOSYNTHESIS, AND MITOCHONDRIAL MORPHOLOGY
2020
Authors: Elizabeth A Walden, Roger Y Fong, Trang T Pham, Hana Knill, Sarah Jane Laframboise, Sylvain Huard, Mary-Ellen Harper*, Kristin Baetz
Journal: PLoS genetics
METABOLIC TERMINOLOGY: WHAT’S IN A NAME?
2020
Authors: Mary-Ellen Harper* and Mary Elizabeth Patti.
Journal: Nature Metabolism. 2: 476-477.
Pubmed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475284/
SGCG RS679482 ASSOCIATES WITH WEIGHT LOSS SUCCESS IN RESPONSE TO AN INTENSIVELY SUPERVISED OUTPATIENT PROGRAM
2020
Authors: Majid Nikpay, Paulina Lau, Sebastien Soubeyrand, Katey Whytlock, Kaitlyn Beecher, Chantal Pileggi*, Sujoy Ghosh, Mary-Ellen Harper*, Robert Dent, and Ruth McPherson
Journal: Diabetes
GLUTAREDOXIN-2 AND SIRTUIN-3 DEFICIENCIES IMPAIR CARDIAC MITOCHONDRIAL ENERGETICS BUT THEIR EFFECTS ARE NOT ADDITIVE.
2020
Authors: Neoma T Boardman*, Baher Migally*, Chantal Pileggi*, Gaganvir S Parmar*, Jian Ying Xuan*, Keir Menzies and Mary-Ellen Harper*
Journal: BBA: Molecular Basis of Disease.
HARNESSING THE PROTECTIVE ROLE OF OPA1 IN DIABETIC CARDIOMYOPATHY.
2020
Authors: David A. Patten*, Mary-Ellen Harper* and Neoma Boardman*
Journal: Acta Physiologica (Oxford). 229(1):e13466
Pubmed:https://pubmed.ncbi.nlm.nih.gov/32175678/
MATERNAL DIET INDUCED OBESITY ALTERS MUSCLE MITOCHONDRIAL FUNCTION IN OFFSPRING WITHOUT CHANGING INSULIN SENSITIVITY.
2019
Authors: Fiona McMurray*, Megan MacFarlane*, Kijoo Kim*, David A. Patten*, Lan Wei-LaPierre, Morgan D. Fullerton, and Mary-Ellen Harper
Journal: FASEB J. 33(12):13515-13526
MITOCHONDRIAL ADAPTATION IN HUMAN MESENCHYMAL STEM CELLS FOLLOWING IONIZING RADIATION.
2019
Authors: David A. Patten*, Mathieu Ouelet, David S. Allan, Marc Germain, Stephen Baird, Mary-Ellen Harper* and Richard B. Richardson
Journal: FASEB J. 33 (8), 9263-9278
Pubmed: https://pubmed.ncbi.nlm.nih.gov/31112400/
SIRT3 CONTROLS BROWN FAT THERMOGENESIS BY DEACETYLATION REGULATION OF PATHWAYS UPSTREAM OF UCP1.
2019
Authors: Rajaa Sebaa*, Jeff Johnson, Chantal Pileggi*, Michaela Norgren*, Jian Xuan*, Yuka Sai, Qiang Tong, Irena Krystkowiak, Emma Bondy-Chorney, Norman Davey, Nevan Krogan, Michael Downey+ and Mary-Ellen Harper+
Journal: Molecular Metabolism. 25:35-49
GLYOXALASE 1 PREVENTS CHRONIC HYPERGLYCEMIA INDUCED HEART-EXPLANT DERIVED CELL DYSFUNCTION
2019
Authors: Melanie Villanueva, Connor Michie, Georges N Kanaan*, Ghazaleh Rafatian, Pushpinder Kanda, Bin Ye, Wenbin Liang, Mary-Ellen Harper* and Darryl R Davis
Journal: Theranostics
EXERCISE PLASMA METABOLOMICS AND XENOMETABOLOMICS IN OBESE, SEDENTARY, INSULIN-RESISTANT WOMEN: IMPACT OF A FITNESS AND WEIGHT LOSS INTERVENTION.
2019
Authors: Dmitry Grapov, Oliver Fiehn, Caitlin Campbell, Carol Chandler, Dustin Burnett, Elaine Souza, Gretchen Casazza, Nancy Keim, John Newman, Gary Hunter, Jose Fernandez, W. Timothy Garvey, Charles Hoppel, Mary-Ellen Harper*, and Sean H. Adams
Journal: American Journal of Physiology- Endocrinology and Metabolism
SKELETAL MUSCLE MITOFLASHES, PH, AND THE ROLE OF UNCOUPLING PROTEIN-3.
2019
Authors: Skye McBride*, Lan Wei-LaPierre, Fiona McMurray*, Megan MacFarlane*, Xing Qiu, David A. Patten*, Robert T. Dirksen RT, Mary-Ellen Harper*
Journal: Arch Biochem Biophys. 663:239-248.
GENOME-WIDE IDENTIFICATION OF CIRCULATING-MIRNA EXPRESSION QUANTITATIVE TRAIT LOCI REVEALS THE ROLE OF SEVERAL MIRNAS IN THE REGULATION OF CARDIOMETABOLIC PHENOTYPES
2019
Authors: Majid Nikpay, Kaitlyn Beehler, Armand Valsesia, Jorg Hager, Mary-Ellen Harper*, Robert Dent, and Ruth McPherson
Journal: Cardiovascular Research
ATRIAL FIBRILLATION IS ASSOCIATED WITH IMPAIRED ATRIAL MITOCHONDRIAL ENERGETICS AND SUPERCOMPLEX FORMATION IN TYPE 2 DIABETES.
2019
Authors: Georges Kanaan*, David Patten*, Calum Redpath and Mary-Ellen Harper*.
Journal: Canadian Journal of Diabetes. 43(1):67-75.
INFLUENCE OF ACSL5 GENOTYPE ON FATTY ACID OXIDATION AND MITOCHONDRIAL BIOENERGETICS -AN IN VITRO, EX VIVO AND IN VIVO ANALYSIS.
2018
Authors: Abi Rajkumar*, Awa Liaghati*, Jessica Chan, Gilles Lamothe, Robert Dent, Éric Doucet, Remi Rabasa-Lhoret, Denis Prud’homme, Mary-Ellen Harper** and Frédérique Tesson**
Journal: Metabolism Clinical and Experimental. 83:271-279.
EFFECTS OF COBALT AND CHROMIUM IONS ON OXIDATIVE STRESS AND CELLULAR ENERGETICS IN MACROPHAGES IN VITRO.
2018
Authors: Zeina Salloum, Eric Lehoux, Mary-Ellen Harper* and Isabelle Catalas
Journal: Journal of Orthopaedic Research
DIET-RESISTANT OBESITY IS CHARACTERIZED BY A DISTINCT PLASMA PROTEOMIC SIGNATURE AND IMPAIRED MUSCLE FIBER METABOLISM
2018
Authors: A. Brianne Thrush*, Ghadi Antoun*, Majid Nikpay, Jean-François Mauger, David Patten*, Brittany L. Beauchamp*, Paulina Lau, Éric Doucet, Pascal Imbeault, Robert Boushel, Jorg Hager, Armand Valsesia, Ruth Slack, Osama Y. Al-Dirbashi, Robert Dent**, Ruth McPherson** and Mary-Ellen Harper**.
Journal: Int J Obesity. 42(3):353-362
TUMOR METABOLISM REGULATING CHEMOSENSITIVITY IN OVARIAN CANCER. GENES AND CANCER.
2018
Authors: Chae Young Han, David A Patten*, Richard Richardson, Mary-Ellen Harper*, and Benjamin K. Tsang.
Journal: Genes and Cancer.
IL-15 IMPROVES SKELETAL MUSCLE OXIDATIVE METABOLISM AND GLUCOSE UPTAKE IN ASSOCIATION WITH INCREASED RESPIRATORY CHAIN SUPERCOMPLEX FORMATION AND AMPK PATHWAY ACTIVATION.
2019
Authors: Lucien Nadeau*, David Patten*, Audrey Caron, Léa Garneau, Marc Foretz, Pascal Haddad, Barbara G Andersen, Quinn LeBris, Mary-Ellen Harper*, and Céline Aguer.
Journal: BBA General Subjects. 1863(2):395-407
Pubmed: https://pubmed.ncbi.nlm.nih.gov/30448294/
GLUTAREDOXIN-2 CONTROLS CARDIAC MITOCHONDRIAL DYNAMICS AND ENERGETICS IN MICE, AND PROTECTS AGAINST HUMAN CARDIAC PATHOLOGIES.
2018
Authors: Georges N. Kanaan*, Bianca Ichim*, Lara Gharibeh, Wael Maharsy, David Patten*, Jian Ying Xuan*, Arkadiy Reunov, Philip Marshall, John Veinot, Keir Menzies, Mona Nemer and Mary-Ellen Harper*
Journal: Redox Biol. 14:509-521.
IS TYPE 2 DIABETES ASSOCIATED WITH IMPAIRED CAPACITY FOR WEIGHT LOSS?
2018
Authors: Ghadi Antoun*, Majid Nikpay, Ruth McPherson, Mary-Ellen Harper*, and Robert Dent.
Journal: Can J Diabetes. 42(3):313-16.
Pubmed: https://pubmed.ncbi.nlm.nih.gov/28800932/
CELLULAR REDOX DYSFUNCTION IN THE DEVELOPMENT OF CARDIOVASCULAR DISEASES.
2017
Authors: Georges N. Kanaan* and Mary-Ellen Harper*
Journal: BBA: General Subjects. 1861: 2822-9.
A NOVEL AMINO ACID AND METABOLOMICS SIGNATURE IN MICE OVEREXPRESSING MUSCLE UNCOUPLING PROTEIN 3.
2017
Authors: Céline Aguer*, Brian Piccolo, Oliver Fiehn, Sean Adams and Mary-Ellen Harper*
Journal: FASEB J. 31(2):814-27.
EFFECTS OF 12 MONTHS OF CALORIC RESTRICTION ON MUSCLE MITOCHONDRIAL FUNCTION IN HEALTHY INDIVIDUALS
2017
Authors: Sparks LM, Redman LM, Conley KE, Harper ME*, Yi F, Hodges A, Eroshkin A, Costford SR, Gabriel ME, Shook C, Cornnell HH, Ravussin E, Smith SR.
Journal: J Clin Endocrinol Metab
DETAILED BIOCHEMICAL AND BIOENERGETIC CHARACTERIZATION OF FBXL4-RELATED ENCEPHALOMYOPATHIC MITOCHONDRIAL DNA DEPLETION
2016
Authors: Ghadi Antoun*, Skye McBride*, Jason R. Vanstone, Turaya Naas, Jean Michaud, Hugh McMillan, Stephanie Redpath, Dennis Bulman, Jason Brophy, FORGE Canada Consortium, Kym M. Boycott, David Dyment, Martin Holcik, Alex Mackenzie, Mary-Ellen Harper*+, and Matthew A. Lines+
Journal: Journal of Inherited Metabolic Diseases
IDENTIFICATION OF A PATHOGENIC FTO MUTATION BY NEXT-GENERATION SEQUENCING IN A NEWBORN WITH GROWTH RETARDATION AND DEVELOPMENTAL DELAY
2016
Authors: Hussein Daoud, Fiona McMurray*, Andrea Yu, Stephanie Luco, Jason Vanstone, Olga Jarinova, Nancy Carson, Kym M Boycott, Christopher Schofield, Mary-Ellen Harper*, David A Dyment, Christine M Armour.
Journal: Journal of Medical Genetics
