SELECTED PUBLICATIONS

Some of our highlighted publications.  For a complete list, please refer to PubMed or Google Scholar.

* Denotes a member of the Harper Lab at the time of publication

2020

ROLE OF GLUTATHIONE IN CANCER: FROM MECHANISMS TO THERAPIES

Authors: Luke Kennedy*, Jagdeep Sanhu, Mary-Ellen Harper* and Miroslava Cuperlovic-Culf

Journal: Biomolecules

Pubmed: In Press

2020

THE LIFECYCLE OF SKELETAL MUSCLE MITOCHONDRIA IN OBESITY

Authors: Chantal Pileggi*, Gaganvir Parmar*, and Mary-Ellen Harper*

Journal: Obesity Reviews

Pubmed: In Press

2020

FACTORS AFFECTING WEIGHT LOSS VARIABILITY IN OBESITY

Authors: Robert Dent, Ruth McPherson and Mary-Ellen Harper*

Journal: Metabolism Clinical and Experimental

Pubmed: In Press

2020

GLUTAREDOXIN-2 AND SIRTUIN-3 DEFICIENCIES IMPAIR CARDIAC MITOCHONDRIAL ENERGETICS BUT THEIR EFFECTS ARE NOT ADDITIVE.

Authors: Neoma T Boardman*, Baher Migally*, Chantal Pileggi*, Gaganvir S Parmar*, Jian Ying Xuan*, Keir Menzies and Mary-Ellen Harper* 

Journal: BBA: Molecular Basis of Disease.

Pudmed: https://pubmed.ncbi.nlm.nih.gov/33002579/ 

2020

ALTERED MITOCHONDRIAL FUSION DRIVES DEFENSIVE GLUTATHIONE SYNTHESIS IN CELLS ABLE TO SWITCH TO GLYCOLYTIC ATP PRODUCTION

Authors: David A. Patten*, Shawn McGuirk, Ujval Anilkumar, Ghadi Antoun*, Karan Gandhi*, Gaganvir Parma*, Mohamed Ariff Iqbal, Jacob Wong, Richard B.Richardson, Julie St-Pierre, Ruth S.Slack, Mary-Ellen Harper*

Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Link: https://www.sciencedirect.com/science/article/pii/S0167488920302123

2020

METABOLIC TERMINOLOGY: WHAT’S IN A NAME?

Authors: Mary-Ellen Harper* and Mary Elizabeth Patti.

Journal: Nature Metabolism. 2: 476-477.

Pubmed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475284/

2020

SGCG RS679482 ASSOCIATES WITH WEIGHT LOSS SUCCESS IN RESPONSE TO AN INTENSIVELY SUPERVISED OUTPATIENT PROGRAM

Authors: Majid Nikpay, Paulina Lau, Sebastien Soubeyrand, Katey  Whytlock, Kaitlyn Beecher, Chantal Pileggi*, Sujoy Ghosh, Mary-Ellen Harper*, Robert Dent, and Ruth McPherson

Journal: Diabetes

Pubmed: https://pubmed.ncbi.nlm.nih.gov/32527767/

2020

HARNESSING THE PROTECTIVE ROLE OF OPA1 IN DIABETIC CARDIOMYOPATHY.

Authors: David A. Patten*, Mary-Ellen Harper* and Neoma Boardman*

Journal: Acta Physiologica (Oxford). 229(1):e13466

Pubmed:https://pubmed.ncbi.nlm.nih.gov/32175678/

2019

MATERNAL DIET INDUCED OBESITY ALTERS MUSCLE MITOCHONDRIAL FUNCTION IN OFFSPRING WITHOUT CHANGING INSULIN SENSITIVITY.

Authors: Fiona McMurray*, Megan MacFarlane*, Kijoo Kim*, David A. Patten*, Lan Wei-LaPierre, Morgan D. Fullerton, and Mary-Ellen Harper

Journal: FASEB J. 33(12):13515-13526

Pubmed: https://pubmed.ncbi.nlm.nih.gov/31581846/

2019

MITOCHONDRIAL ADAPTATION IN HUMAN MESENCHYMAL STEM CELLS FOLLOWING IONIZING RADIATION.

Authors: David A. Patten*, Mathieu Ouelet, David S. Allan, Marc Germain, Stephen Baird, Mary-Ellen Harper* and Richard B. Richardson

Journal: FASEB J. 33 (8), 9263-9278  

Pubmed: https://pubmed.ncbi.nlm.nih.gov/31112400/

2019

SIRT3 CONTROLS BROWN FAT THERMOGENESIS BY DEACETYLATION REGULATION OF PATHWAYS UPSTREAM OF UCP1.

Authors: Rajaa Sebaa*, Jeff Johnson, Chantal Pileggi*, Michaela Norgren*, Jian Xuan*, Yuka Sai, Qiang Tong, Irena Krystkowiak, Emma Bondy-Chorney, Norman Davey, Nevan Krogan, Michael Downey+ and Mary-Ellen Harper+

Journal: Molecular Metabolism. 25:35-49

Pubmed: https://pubmed.ncbi.nlm.nih.gov/31060926/

2019

GLYOXALASE 1 PREVENTS CHRONIC HYPERGLYCEMIA INDUCED HEART-EXPLANT DERIVED CELL DYSFUNCTION

Authors: Melanie Villanueva, Connor Michie, Georges N Kanaan*, Ghazaleh Rafatian, Pushpinder Kanda, Bin Ye, Wenbin Liang, Mary-Ellen Harper* and Darryl R Davis

Journal: Theranostics

Pubmed: https://pubmed.ncbi.nlm.nih.gov/31534514/

2019

EXERCISE PLASMA METABOLOMICS AND XENOMETABOLOMICS IN OBESE, SEDENTARY, INSULIN-RESISTANT WOMEN: IMPACT OF A FITNESS AND WEIGHT LOSS INTERVENTION.

Authors: Dmitry Grapov, Oliver Fiehn, Caitlin Campbell, Carol Chandler, Dustin Burnett, Elaine Souza, Gretchen Casazza, Nancy Keim, John Newman, Gary Hunter, Jose Fernandez, W. Timothy Garvey, Charles Hoppel, Mary-Ellen Harper*, and Sean H. Adams

Journal: American Journal of Physiology- Endocrinology and Metabolism

Pubmed: https://pubmed.ncbi.nlm.nih.gov/31526287/ 

2019

SKELETAL MUSCLE MITOFLASHES, PH, AND THE ROLE OF UNCOUPLING PROTEIN-3.

Authors: Skye McBride*, Lan Wei-LaPierre, Fiona McMurray*, Megan MacFarlane*, Xing Qiu, David A. Patten*, Robert T. Dirksen RT, Mary-Ellen Harper*

Journal: Arch Biochem Biophys. 663:239-248.

Pubmed: https://pubmed.ncbi.nlm.nih.gov/30659802/

2019

GENOME-WIDE IDENTIFICATION OF CIRCULATING-MIRNA EXPRESSION QUANTITATIVE TRAIT LOCI REVEALS THE ROLE OF SEVERAL MIRNAS IN THE REGULATION OF CARDIOMETABOLIC PHENOTYPES

Authors: Majid Nikpay, Kaitlyn Beehler, Armand Valsesia, Jorg Hager, Mary-Ellen Harper*, Robert Dent, and Ruth McPherson

Journal: Cardiovascular Research

Pubmed: https://pubmed.ncbi.nlm.nih.gov/30715214/

2019

ATRIAL FIBRILLATION IS ASSOCIATED WITH IMPAIRED ATRIAL MITOCHONDRIAL ENERGETICS AND SUPERCOMPLEX FORMATION IN TYPE 2 DIABETES.

Authors: Georges Kanaan*, David Patten*, Calum Redpath and Mary-Ellen Harper*.

Journal: Canadian Journal of Diabetes. 43(1):67-75.

Pubmed: https://pubmed.ncbi.nlm.nih.gov/30146472/

2018

EFFECTS OF COBALT AND CHROMIUM IONS ON OXIDATIVE STRESS AND CELLULAR ENERGETICS IN MACROPHAGES IN VITRO.

Authors: Zeina Salloum, Eric Lehoux, Mary-Ellen Harper* and Isabelle Catalas

Journal: Journal of Orthopaedic Research

Pubmed: https://pubmed.ncbi.nlm.nih.gov/30144138/

2018

INFLUENCE OF ACSL5 GENOTYPE ON FATTY ACID OXIDATION AND MITOCHONDRIAL BIOENERGETICS -AN IN VITRO, EX VIVO AND IN VIVO ANALYSIS.

Authors: Abi Rajkumar*, Awa Liaghati*, Jessica Chan, Gilles Lamothe, Robert Dent, Éric Doucet, Remi Rabasa-Lhoret, Denis Prud’homme, Mary-Ellen Harper** and Frédérique Tesson**

Journal: Metabolism Clinical and Experimental. 83:271-279.

Pubmed: https://pubmed.ncbi.nlm.nih.gov/29605434/

2018

DIET-RESISTANT OBESITY IS CHARACTERIZED BY A DISTINCT PLASMA PROTEOMIC SIGNATURE AND IMPAIRED MUSCLE FIBER METABOLISM

Authors: A. Brianne Thrush*, Ghadi Antoun*, Majid Nikpay, Jean-François Mauger, David Patten*, Brittany L. Beauchamp*, Paulina Lau, Éric Doucet, Pascal Imbeault, Robert Boushel, Jorg Hager, Armand Valsesia, Ruth Slack, Osama Y. Al-Dirbashi, Robert Dent**, Ruth McPherson** and Mary-Ellen Harper**.

Journal: Int J Obesity. 42(3):353-362

Pubmed: https://pubmed.ncbi.nlm.nih.gov/29151592/

2018

TUMOR METABOLISM REGULATING CHEMOSENSITIVITY IN OVARIAN CANCER. GENES AND CANCER.

Authors: Chae Young Han, David A Patten*, Richard Richardson, Mary-Ellen Harper*, and Benjamin K. Tsang.

Journal: Genes and Cancer.

Pubmed: https://pubmed.ncbi.nlm.nih.gov/30603053/

2019

IL-15 IMPROVES SKELETAL MUSCLE OXIDATIVE METABOLISM AND GLUCOSE UPTAKE IN ASSOCIATION WITH INCREASED RESPIRATORY CHAIN SUPERCOMPLEX FORMATION AND AMPK PATHWAY ACTIVATION.

Authors: Lucien Nadeau*, David Patten*, Audrey Caron, Léa Garneau, Marc Foretz, Pascal Haddad, Barbara G Andersen, Quinn LeBris, Mary-Ellen Harper*, and Céline Aguer.

Journal: BBA General Subjects. 1863(2):395-407

Pubmed: https://pubmed.ncbi.nlm.nih.gov/30448294/


2018

GLUTAREDOXIN-2 CONTROLS CARDIAC MITOCHONDRIAL DYNAMICS AND ENERGETICS IN MICE, AND PROTECTS AGAINST HUMAN CARDIAC PATHOLOGIES.

Authors: Georges N. Kanaan*, Bianca Ichim*, Lara Gharibeh, Wael Maharsy, David Patten*, Jian Ying Xuan*, Arkadiy Reunov, Philip Marshall, John Veinot, Keir Menzies, Mona Nemer and Mary-Ellen Harper*

Journal: Redox Biol. 14:509-521.

Pubmed: https://pubmed.ncbi.nlm.nih.gov/29101900/

2018

IS TYPE 2 DIABETES ASSOCIATED WITH IMPAIRED CAPACITY FOR WEIGHT LOSS?

Authors: Ghadi Antoun*, Majid Nikpay, Ruth McPherson, Mary-Ellen Harper*, and Robert Dent.

Journal: Can J Diabetes. 42(3):313-16.

Pubmed: https://pubmed.ncbi.nlm.nih.gov/28800932/

2017

CELLULAR REDOX DYSFUNCTION IN THE DEVELOPMENT OF CARDIOVASCULAR DISEASES.

Authors: Georges N. Kanaan* and Mary-Ellen Harper*

Journal: BBA: General Subjects. 1861: 2822-9.

Pubmed: https://pubmed.ncbi.nlm.nih.gov/28778485/

2017

A NOVEL AMINO ACID AND METABOLOMICS SIGNATURE IN MICE OVEREXPRESSING MUSCLE UNCOUPLING PROTEIN 3.

Authors: Céline Aguer*, Brian Piccolo, Oliver Fiehn, Sean Adams and Mary-Ellen Harper*

Journal: FASEB J. 31(2):814-27.

Pubmed: https://pubmed.ncbi.nlm.nih.gov/27871066/

2017

EFFECTS OF 12 MONTHS OF CALORIC RESTRICTION ON MUSCLE MITOCHONDRIAL FUNCTION IN HEALTHY INDIVIDUALS

Authors: Sparks LM, Redman LM, Conley KE, Harper ME*, Yi F, Hodges A, Eroshkin A, Costford SR, Gabriel ME, Shook C, Cornnell HH, Ravussin E, Smith SR.

Journal: J Clin Endocrinol Metab

Pubmed: https://pubmed.ncbi.nlm.nih.gov/27778643/

2016

DRUGS AND BUGS: TURNING ON THE HEAT THROUGH UCP1 AND UCP3

Authors: Mary-Ellen Harper*

Journal: J. Physiol. 594(24):7151-2.

Pubmed: https://pubmed.ncbi.nlm.nih.gov/27976394/

2016

REACTIVE OXYGEN SPECIES AND OXIDATIVE STRESS IN OBESITY – RECENT FINDINGS AND EMPIRICAL APPROACHES.

Authors: Fiona McMurray*, David A. Patten* and Mary-Ellen Harper*

Journal: Obesity. 24(11):2301-10.

Pubmed: https://pubmed.ncbi.nlm.nih.gov/27804267/

2016

FOUR-WEEK COLD ACCLIMATION IN ADULT HUMANS SHIFTS UNCOUPLING THERMOGENESIS FROM SKELETAL MUSCLES TO BAT.

Authors: Denis P. Blondin, Amani Daoud, Taryn Taylor, Hans C. Tingelstad, Véronic Bézaire*, Denis Richard, André C. Carpentier, Albert W. Taylor, Mary-Ellen Harper*, Céline Aguer*, François Haman.

Journal: J Physiol. 595(6):2099-113.

Pubmed: https://pubmed.ncbi.nlm.nih.gov/28025824/

2016

DIFFERENCES IN MITOCHONDRIAL COUPLING REVEAL A NOVEL SIGNATURE OF MITOHORMESIS IN MUSCLE OF HEALTHY INDIVIDUALS.

Authors:  Sparks LM, Redman LM, Conley KE, Harper ME*, Hodges A, Eroshkin A, Costford SR, Gabriel ME, Yi F, Shook C, Cornnell HH, Ravussin E, Smith SR.

Journal: . J Clin Endocrinol Metab. 

Pubmed: https://pubmed.ncbi.nlm.nih.gov/27710240/

2016

ACYL-COA SYNTHETASE LONG-CHAIN 5 GENOTYPE IS ASSOCIATED WITH BODY COMPOSITION CHANGES IN RESPONSE TO LIFESTYLE INTERVENTIONS IN POSTMENOPAUSAL WOMEN WITH OVERWEIGHT AND OBESITY: A GENETIC ASSOCIATION STUDY ON COHORTS MONTRÉAL-OTTAWA NEW EMERGING TEAM, AND COMPLICATIONS ASSOCIATED WITH OBESITY.

Authors: Abi Rajkumar*, Gilles Lamothe, Pierette Bolongo, Mary-Ellen Harper*, Kristi Adamo, Eric Doucet, Remi Rabasa-Lhoret, Denis Prud'homme, Frederique Tesson

Journal: BMC Med Genet

Pubmed: https://pubmed.ncbi.nlm.nih.gov/27515448/

2016

KATP CHANNEL DEFICIENCY IN MOUSE FDB CAUSES AN IMPAIRMENT OF ENERGY METABOLISM DURING FATIGUE

Authors: Kyle Scott, Maria Benkhalti Jandu, Nicholas D. Calvert, Mathieu Paquette, Li Zhen, Mary-Ellen Harper*, Osama Y. Al-Dirbashi, and Jean-Marc Renaud

Journal: Am. J. Physiol: Cell

Pubmed: https://pubmed.ncbi.nlm.nih.gov/27488667/

2016

SEVERE NEONATAL PRESENTATION OF MITOCHONDRIAL CITRATE CARRIER (SLC25A1) DEFICIENCY

Authors:  L. Marcadier, Jean Michaud, Osama Y. Al-Dirbashi, Jeremy Schwartzentruber, Chandree L. Beaulieu, Sherri L. Katz, FORGE Canada Consortium, Jacek Majewski, Dennis E. Bulman, Michael T. Geraghty, Mary-Ellen Harper*, Pranesh Chakraborty , Matthew A. Lines

Journal: J. Inher. Metab. Diseases 

Pubmed: https://pubmed.ncbi.nlm.nih.gov/27306203/

2016

MITOCHONDRIAL DYNAMICS IMPACTS STEM CELL IDENTITY AND FATE DECISIONS BY REGULATING A NUCLEAR TRANSCRIPTIONAL PROGRAM

Authors: Mireille Khacho, Alysen Clark, Devon S. Svoboda, Joelle Azzi, Jason G. MacLaurin, Cynthia

Meghaizel, Hiromi Sesaki, Diane C. Lagace, Marc Germain, Mary-Ellen Harper*, David S. Park, Ruth S. Slack.

Journal: Cell Stem Cell

Pubmed: https://pubmed.ncbi.nlm.nih.gov/27237737/

2016

MITOCHONDRIAL STRESS CONTROLS THE RADIOSENSITIVITY OF THE OXYGEN EFFECT: IMPLICATIONS FOR RADIOTHERAPY.

Authors: Richard B Richardson and Mary-Ellen Harper*

Journal: Oncotarget

Pubmed: https://pubmed.ncbi.nlm.nih.gov/26894978/

2016

IN UTERO UNDERNUTRITION PROGRAMS SKELETAL AND CARDIAC MUSCLE METABOLISM

Authors: Brittany Beauchamp* and Mary-Ellen Harper*

Journal: Frontiers in Physiology

Pubmed: https://pubmed.ncbi.nlm.nih.gov/26779032/

2016

A SIGNALING LIPID ASSOCIATED WITH ALZHEIMER’S DISEASE CAUSES MITOCHONDRIAL DYSFUNCTION

Authors: Michael A. Kennedy, Tia C. Moffat, Kenneth Gable, Karolina Niewola-Staszkowska, Anne Johnston, Corey Nislow, Linda J. Harris, Robbie Loewith, Mary-Ellen Harper*, Teresa Dunn, Steffany Bennett and Kristin Baetz

Journal: Scientific Reports

Pubmed: https://pubmed.ncbi.nlm.nih.gov/26757638/

2016

DETAILED BIOCHEMICAL AND BIOENERGETIC CHARACTERIZATION OF FBXL4-RELATED ENCEPHALOMYOPATHIC MITOCHONDRIAL DNA DEPLETION

Authors: Ghadi Antoun*, Skye McBride*, Jason R. Vanstone, Turaya Naas, Jean Michaud, Hugh McMillan, Stephanie Redpath, Dennis Bulman, Jason Brophy, FORGE Canada Consortium, Kym M. Boycott, David Dyment, Martin Holcik, Alex Mackenzie, Mary-Ellen Harper*+, and Matthew A. Lines+

Journal: Journal of Inherited Metabolic Diseases

Pubmed: https://pubmed.ncbi.nlm.nih.gov/26404457/

2016

IDENTIFICATION OF A PATHOGENIC FTO MUTATION BY NEXT-GENERATION SEQUENCING IN A NEWBORN WITH GROWTH RETARDATION AND DEVELOPMENTAL DELAY

Authors: Hussein Daoud, Fiona McMurray*, Andrea Yu, Stephanie Luco, Jason Vanstone, Olga Jarinova, Nancy Carson, Kym M Boycott, Christopher Schofield, Mary-Ellen Harper*, David A Dyment, Christine M Armour.

Journal: Journal of Medical Genetics

Pubmed: https://pubmed.ncbi.nlm.nih.gov/26378117/

2016

CAN RESPONSE TO DIETARY RESTRICTION PREDICT WEIGHT LOSS AFTER ROUX-EN-Y GASTROPLASTY?

Authors: Mirna Azar, Majid Nikpay, Mary-Ellen Harper*, Ruth McPherson, and Robert Dent.


Journal: Obesity


Pubmed: https://pubmed.ncbi.nlm.nih.gov/26853430/

2015

IMPAIRED MITOCHONDRIAL OXIDATIVE PHOSPHORYLATION AND SUPERCOMPLEX ASSEMBLY IN RECTUS ABDOMINIS OF DIABETIC OBESE INDIVIDUALS.

Authors: Ghadi Antoun*, Fiona McMurray*, A Brianne Thrush*, David A Patten, Alyssa Christine Peixoto*, Ruth S Slack, Ruth McPherson, Robert Dent, and Mary-Ellen Harper*


Journal: Diabetologia


Pubmed: https://pubmed.ncbi.nlm.nih.gov/26404066/

2015

ADVERSE EFFECTS OF BETA-BLOCKER THERAPY ON WEIGHT LOSS IN RESPONSE TO A CONTROLLED DIETARY REGIMEN

Authors: Mirna Azar, Majid Nikpay, Mary-Ellen Harper*, Ruth McPherson, and Robert Dent


Journal: Can. J. Cardiol.


Pubmed: https://pubmed.ncbi.nlm.nih.gov/26897181/

2016

DNM1L-RELATED MITOCHONDRIAL FISSION DEFECT PRESENTING AS REFRACTORY EPILEPSY

Authors: Jason Vanstone, Amanda Smith, Skye McBride*, Turaya Naas, Martin Holcik, Ghadi Antoun*, Mary-Ellen Harper*, Jean Michaud, Erick Sell, Pranesh Chakraborty, Martine Tetreault, Jacek Majewski, Stephen Baird, Kym Boycott, David Dyment, and Alex MacKenzie and Matthew Lines*


Journal: Eur. J. Human Genetics 


Pubmed: https://pubmed.ncbi.nlm.nih.gov/26604000/

2015

THERAPEUTIC INHIBITION OF MIR-33 PROMOTES FATTY ACID OXIDATION BUT DOES NOT AMELIORATE METABOLIC DYSFUNCTION IN DIET-INDUCED OBESITY

Authors: Denuja Karunakaran, Laura Richards, Michele Geoffrion, Danyk Barrette, Ryan Gotfrit, Mary-Ellen Harper*, and Katey Rayner


Journal: Arteriosclerosis, Thrombosis, and Vascular Biology


Pubmed: https://pubmed.ncbi.nlm.nih.gov/26427794/

2015

MACROPHAGE MITOCHONDRIAL ENERGY STATUS REGULATES CHOLESTEROL EFFLUX AND IS ENHANCED BY ANTI-MIR33 IN ATHEROSCLEROSIS

Authors: Denuja Karunakaran, A. Brianne Thrush*, MA Nguyen, L Richards, Michelle Geoffrion, R Singaravelu, E Ramphos, P Shangari, Michelle Ouimet, John P Pezacki,  Katherine J Moore, L Perisic, L Maegdefessel, U Hedin, Mary-Ellen Harper*, Katey J Rayner


Journal: Circ Res. 


Pubmed: https://pubmed.ncbi.nlm.nih.gov/26002865/

2015

UNDERNUTRITION DURING PREGNANCY IN MICE LEADS TO DYSFUNCTIONAL CARDIAC MUSCLE RESPIRATION IN ADULT OFFSPRING

Authors: Brittany Beauchamp*, A. Brianne Thrush*, Jessica Quizi*, Ghadi Antoun*, Nathan McIntosh*, Osama Y. Al-Dirbashi, Mary-Elizabeth Patti, and Mary-Ellen Harper*


Journal: Biosci Rep


Pubmed: https://pubmed.ncbi.nlm.nih.gov/26182362/

2015

ACYLCARNITINES: POTENTIAL IMPLICATIONS FOR SKELETAL MUSCLE INSULIN RESISTANCE

Authors: Céline Aguer*, Colin S. McCoin, Trina A. Knotts, A. Brianne Thrush*, Kikumi Ono-Moore, Ruth McPherson, Robert Dent, Daniel H. Hwang, Sean H. Adams3, and Mary-Ellen Harper*


Journal: FASEB


Pubmed: https://pubmed.ncbi.nlm.nih.gov/25342132/

 
mito%20in%20cell_edited.png

Working together to understand the cellular "Fires of Life"