SELECTED PUBLICATIONS
Some of our recent highlighted publications.
For a complete list, please refer to PubMed or Google Scholar.
* Denotes a member of the Harper Lab at the time of publication
OPA1 mediates cardiac function and metabolism: in silico and in vivo evidence.
2025
Authors: Claire Fong-McMaster*, Serena M. Pulente, Luke Kennedy*, Tyler K.T. Smith, Stephanie Myers*, Michel Kanaan*, Charbel Karam*, Matthew Cope*, Ilka Lorenzen-Schmidt, Craig J. Goergen, Morgan D. Fullerton, Miroslava Cuperlovic-Culf, Erin E. Mulvihill, and Mary-Ellen Harper.
Preprint at bioRxiv.org
Accessory Subunit NDUFB4 Participates in Mitochondrial Complex I Supercomplex Formation
February 2024
Authors: Gaganvir Parmar*, Claire Fong-McMaster*, Chantal A Pileggi*, David A Patten*, Alexanne Cuillerier, Stephanie Myers*, Ying Wang, Siegfried Hekimi, Miroslava Cuperlovic-Culf, Mary-Ellen Harper
Journal: Journal of Biological Chemistry
The SARS-CoV-2 spike glycoprotein interacts with MAO-B and impairs mitochondrial energetics
October 2023
Authors: Chantal A Pileggi*, Gaganvir Parmar*, Hussein Elkhatib*, Corina M Stewart, Irina Alecu, Marceline Côté, Steffany AL Bennett, Jagdeep K Sandhu, Miroslava Cuperlovic-Culf, Mary-Ellen Harper
Journal: Current Research in Neurobiology
GDF15 promotes weight loss by enhancing energy expenditure in muscle
October 2023
Authors: Dongdong Wang, Logan K Townsend, Geneviève J DesOrmeaux, Sara M Frangos, Battsetseg Batchuluun, Lauralyne Dumont, Rune Ehrenreich Kuhre, Elham Ahmadi, Sumei Hu, Irena A Rebalka, Jaya Gautam, Maria Joy Therese Jabile, Chantal A Pileggi*, Sonia Rehal, Eric M Desjardins, Evangelia E Tsakiridis, James SV Lally, Emma Sara Juracic, A Russell Tupling, Hertzel C Gerstein, Guillaume Paré, Theodoros Tsakiridis, Mary-Ellen Harper, Thomas J Hawke, John R Speakman, Denis P Blondin, Graham P Holloway, Sebastian Beck Jørgensen, Gregory R Steinberg
Journal: Nature
The TNFα/TNFR2 axis mediates natural killer cell proliferation by promoting aerobic glycolysis
October 2023
Authors: Abrar Ul Haq Khan, Alaa Kassim Ali, Bryan Marr, Donghyeon Jo, Simin Ahmadvand, Claire Fong-McMaster*, Saeedah Musaed Almutairi, Lisheng Wang, Subash Sad,
Mary-Ellen Harper, Seung-Hwan Lee
Journal: Cellular & Molecular Immunology
Novel Homozygous Variant in COQ7 in Siblings With Hereditary Motor Neuropathy
January 2023
Authors: Ian C Smith, Chantal A Pileggi*, Ying Wang, Kristin Kernohan, Taila Hartley, Hugh J McMillan, Marcos Loreto Sampaio, Gerd Melkus, John Woulfe, Gaganvir Parmar, Pierre R Bourque, Ari Breiner, Jocelyn Zwicker, C Elizabeth Pringle, Olga Jarinova, Hanns Lochmüller, David A Dyment, Bernard Brais, Kym M Boycott, Siegfried Hekimi, Mary-Ellen Harper, Jodi Warman-Chardon
Journal: Neurology Genetics
Exercise training enhances muscle mitochondrial metabolism in diet-resistant obesity
September 2022
Authors: Chantal A Pileggi*, Denis P Blondin*, Breana G Hooks*, Gaganvir Parmar*, Irina Alecu, David A Patten, Alexanne Cuillerier, Conor O'Dwyer, A Brianne Thrush*, Morgan D Fullerton, Steffany AL Bennett, Éric Doucet, François Haman, Miroslava Cuperlovic-Culf, Ruth McPherson, Robert RM Dent, Mary-Ellen Harper
Journal: eBiomedicine
Naked mole-rat brown fat thermogenesis is diminished during hypoxia through a rapid decrease in UCP1
November 2021
Authors: Hang Cheng, Rajaa Sebaa*, Nikita Malholtra, Baptiste Lacoste, Ziyad El Hankouri*, Alexia Kirby, Nigel C Bennett, Barry Van Jaarsveld, Daniel W Hart, Glenn J Tattersall, Mary-Ellen Harper, Matthew E Pamenter
Journal: Nature Communications
Glutaredoxin-2 and Sirtuin-3 deficiencies impair cardiac mitochondrial energetics but their effects are not additive
May 2021
Authors: Neoma T Boardman*, Baher Migally*, Chantal Pileggi*, Gaganvir S Parmar*, Jian Ying Xuan*, Keir Menzies, Mary-Ellen Harper
Journal: Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease
Altered mitochondrial fusion drives defensive glutathione synthesis in cells able to switch to glycolytic ATP production
January 2021
Authors: David A Patten*, Shawn McGuirk, Ujval Anilkumar, Ghadi Antoun, Karan Gandhi, Gaganvir Parmar*, Mohamed Ariff Iqbal, Jacob Wong, Richard B Richardson, Julie St-Pierre, Ruth S Slack, Mary-Ellen Harper
Journal: Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
SIRT3 controls brown fat thermogenesis by deacetylation regulation of pathways upstream of UCP1
July 2019
Authors: Rajaa Sebaa*, Jeff Johnson, Chantal Pileggi*, Michaela Norgren*, Jian Xuan*, Yuka Sai, Qiang Tong, Izabella Krystkowiak, Emma Bondy-Chorney, Norman E Davey, Nevan Krogan, Michael Downey, Mary-Ellen Harper
Journal: Molecular Metabolism
