THE HARPER LABORATORY:
Professor Mary-Ellen Harper, PhD
University Research Chair, Mitochondrial Bioenergetics
Director, Metabolomics Advanced Training and International Exchange (MATRIX), an
NSERC-CREATE Program http://www.matrixmetabolomics.ca
Director, Ottawa Institute of Systems Biology (https://med.uottawa.ca/oisb/)
Department of Biochemistry, Microbiology and Immunology
Faculty of Medicine
University of Ottawa
The Harper laboratory investigates the importance of mitochondria in health and disease.
Mitochondria are remarkable organelles within eukaryotic cells, and are referred to as the cellular powerhouses due to their important role in typically providing ~90% of a cell’s ATP. The Harper laboratory’s research focuses on the mechanisms through which mitochondria transduce the energy substrates, like glucose and fatty acids, into ATP, and this field of research is referred to as ‘bioenergetics’. Cellular energy metabolism becomes disordered in many disease states, and disordered energy metabolism can cause many types of disease. Our research has implications for a better understanding of, and possible novel treatment strategies for diseases including diabetes, obesity, cardiomyopathies, neurodegenerative diseases and cancers.
Mitochondrial bioenergetics is a hub for many physiological and pathological mechanisms, and our research team welcomes trainees at all levels.
Our laboratory is located in the Faculty of Medicine at the University of Ottawa (see map). Get in touch with any questions or comments regarding our work and publications. We’d love to hear from you.
451 Smyth Rd, Ottawa, ON K1H 8M5, Canada